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Trifeme is a type of birth control pill. It offers a very high level of protection from pregnancy if you take it correctly.

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This page was medically reviewed by Dr Lacramioara Burlacu, Prescribing Doctor on August 02, 2022. Next review due on August 01, 2024.

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TrifemeLevonorgestrel and Ethinyl Estradiol

  • 0.05mg - 0.03mg/0.075mg - 0.04mg/0.125mg - 0.03mg
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336 Tablets AUD113.00 Save AUD103.00

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What is Trifeme?

Trifeme is a branded combined contraceptive pill that protects you from getting pregnant. It’s known as a “triphasic” pill, which sounds a bit like something out of a natural history show, but it’s pretty simple. A triphasic pill is a pill that contains three different dosages of progestin and estrogen that you take for 21 days, followed by 7 days of inactive pills with no hormones.

The 21 active pills are three different colours, for each of the three dosages. Six are brown (containing 30/50 micrograms of ethinyl estradiol and levonorgestrel), five are white (containing 40/75 micrograms of ethinyl estradiol and levonorgestrel) and 10 are yellow (containing 30/125 micrograms of ethinyl estradiol and levonorgestrel). So speaking plainly, different pills with different hormones in them.

As a triphasic pill, because it contains different amounts of hormones and mimics the body’s natural cycle very closely, it’s very important that Trifeme pills are taken in the correct order.

How does Trifeme work?

There are three ways in which Trifeme gives you protection from pregnancy. The two hormones in it stop the ovaries from releasing an egg during ovulation, and thicken the mucus in the cervix, which makes it more difficult for sperm to reach an egg. They also make the lining of the uterus thinner, which reduces the chances of a fertilized egg latching on to the uterine wall and growing.

The combined pill tends to make your periods lighter, regular and less painful, so there are additional benefits to taking it too. So it’s an all-round multitasker.

What’s the difference between Trifeme and other pills?

Like other hormonal birth control pills, you take Trifeme at the same time every day. It’s a “combined” pill, so it’s made from a synthetic estrogen and progesterone. There are a few things that make Trifeme special, though.

Trifeme is a triphasic birth control pill while the most common pills are monophasic. Monophasic pills contain one (mono) dose of hormones in all of the active pills. You can guess where we’re going here — Trifeme has three different doses of hormones. (That’s also why it’s called Trifeme!) Changing up the hormone levels is thought to more closely mimic natural hormone fluctuations, which can help with birth control side effects.

Each package of Trifeme comes with 21 active pills and 7 inactive pills, which don’t contain any hormones. That’s because some women prefer to stay in the routine of taking a pill every day, rather than taking a 7-day break, just to reduce the risks of ever forgetting a pill. The extra 7 placebo pills that you get with Trifeme help to provide this security.

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How to take Trifeme pills

Take one pill at the same time every day. It’s best to take your first pill on the first day of your period, as this will give you immediate protection from pregnancy. Start by taking pill number 1, which is a red pill.

Follow the direction of the arrows on the pack until you have taken all 21 active pills. You can swallow each pill whole with water if you prefer to, but don’t chew the pills. Then, you’ll take 7 pills without hormones before starting a new pack.

A couple of days after taking the last active pill, you should get your period. You may still be having your period when you start your next pack of pills; this is absolutely fine and nothing to worry about. It’s important that you start your new pack on time.

So long as you’ve taken your pills correctly and start your next pack of pills when you should, you don’t need to use any additional contraception during your 7 inactive-pill days. Provided that you take Trifeme correctly, you’ll always start a new pack on the same day of the week.

What to do about a Trifeme missed pill

If fewer than 12 hours have passed since you missed a pill, take the pill you missed immediately and any further pill as you would normally, even if this means taking two pills at the same time. Your protection from pregnancy shouldn’t be affected.

Should you find that it’s been more than 12 hours since your missed pill, or if you’ve missed more than one pill, take the pill you missed most recently straight away. Leave any pills you missed earlier than this in the strip. Take any pills that follow at the usual time, even if you have to take two pills in one day. You’ll need to use extra contraception such as a condom for the next 7 days.

Read the patient info that comes with your pill for more info. If you miss a pill towards the end of the pack, you may be advised to skip the inactive pill break and carry straight on to the next pack.

How effective is Trifeme?

When they’re used as they should be, combined pills like Trifeme are more than 99% effective at stopping you from becoming pregnant. So out of 100 women taking them correctly over 12 months, only one will get pregnant.

But if you miss a pill from time to time or if you use combined pills in error, your risk of pregnancy increases slightly. The pill is 91% effective in these circumstances, so for every 100 women taking the pill on this basis, around 9 will become pregnant over 12 months. To avoid this from happening, it’s very important to read the instructions that come with your prescription before you take it.

Medically reviewed by
Dr Lacramioara Burlacu
Prescribing Doctor
on August 02, 2022.
Meet Lacramioara
This page was medically reviewed by Dr Lacramioara Burlacu, Prescribing Doctor on August 02, 2022. Next review due on August 01, 2024.

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When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

FAQ: Trifeme

Have something specific you want to know about Trifeme? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

What ingredients are in Trifeme?

Trifeme consists of two active ingredients, ethinyl estradiol and levonorgestrel, which are artificial hormones that behave in the same way as estrogen and progesterone in the body in preventing pregnancy.

Why are Trifeme pills different colors?

Trifeme strips contain three different dosages of hormones, and the pills are in three different colours, to indicate to you which dosage is which.

Six pills are brown (containing 30/50 micrograms of ethinyl estradiol and levonorgestrel), five pills are white (containing 40/75 micrograms of ethinyl estradiol and levonorgestrel) and 10 pills are yellow (containing 30/125 micrograms of ethinyl estradiol and levonorgestrel).

Because the strips contain pills which have different quantities of hormones in them, it’s especially important to take them in the correct order (by following the arrow on the strip), so that the pills can work effectively.

Can I take Trifeme back-to-back to delay my period?

With Trifeme pills, due to the mix of different hormones in the pills, you should check with the doctor first before taking packs one after another to delay your period.

Can the pill affect my moods?

Some women have reported experiencing depression or low mood whilst using the pill. If you find that your depressive or mood symptoms persist with Trifeme, let our doctor know. They may suggest switching to an alternative pill.

Can Trifeme help treat acne?

In some cases, yes. According to research, hormones in the combined pill can help to manage androgen levels in the body, which keeps the body’s production of sebum (an oily substance in the skin) in check. This in turn helps to keep the pores in the skin clearer, and reduces the number of pimples you might get.

But some people find that the combined pill doesn’t help with acne, and it’s unlikely to fully clear the skin of acne altogether.

Trifeme vs Levlen: what’s the difference?

Trivora and Levlen are both combined hormonal contraceptive pills, and both pills contain the same two hormones, ethinyl estradiol and levonorgestrel.

The difference is that Trifeme is a triphasic pill, whereas Levlen is what we call a monophasic pill, which just means that each pill has the same amount of hormones in it.

In terms of which pill is best for you, it depends on how your body reacts to a higher, lower or a more mixed amount of hormones. The doctor can help to guide you on this during your consultation, taking your medical background and any symptoms or side effects you’ve experienced previously with combined pills into account.

Is Triphasil-28 the same as Trifeme?

The only differences between the Triphasil-28 combined pill and Trifeme are the manufacturer, name and packaging. They contain the same doses of the same hormones, and you take them in the same way. But otherwise, both pills work in the same way, and you take them in the same way.

If I want to switch from Trifeme to another pill, what should I do?

With a Treated subscription, you can switch whenever you want. We like to keep things easy.

Just log in to your account and drop our doctor a message. Taking your medical history and any side effects or symptoms you may get into consideration, they can recommend other pills to you.

Why should I buy Trifeme with Treated?

Prescriptions posted promptly to your door. How does that sound? With a Treated subscription, you can buy Trifeme online and we’ll deliver it to you as often as you need it. Start a consultation to get contraception suggestions from a licensed doctor, and choose an option. They’ll then put together your prescription and our pharmacy will do the rest.

Your first package will be delivered to you in just a few working days and after that, every 3, 6, 9 or 12 months, depending on your preference. No stress. No fuss.
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